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Deemed one of the landmark discoveries of the 20th century, the prostate-specific antigen (PSA) traces its history to Roswell Park Cancer Institute More than two million American men alive in 2008

Cells in the prostate gland produce a protein called prostate-specific antigen (PSA). Semen contains a large volume of PSA, and smaller amounts can be found in the blood.

Research has shown that men with certain risk factors are more likely than others to develop prostate cancer. A risk factor is something that may increase the chance of developing a disease.

The stage is one of the most important factors in selecting treatment options. It is also the most significant (but not the only) factor in predicting a man's outlook for survival (prognosis).

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The prostate gland is located under the bladder and forms a donut-like collar around the urine channel (urethra).